North America dominates the Velaglucerase Alfa market with a 40% share, driven by adoption of advanced therapies, robust infrastructure, and favorable policy frameworks. Europe follows with 30%, supported by mature healthcare ecosystems, investments in rare disease research, and strong demographic demand. The Asia Pacific region, at 15%, is the fastest-growing market, fueled by rising awareness, expanding insurance coverage, and demographic shifts toward urbanization. Latin America (10%) and Middle East & Africa (5%) show incremental growth, driven by improving infrastructure and emerging partnerships to address treatment gaps.