Application segmentation maps TAVR uptake to severity strata and surgical candidacy, providing a clearer demand proxy than aggregate demographics. Severe aortic stenosis (high-risk/inoperable) remains the reimbursement baseline, contributing 70 % of 2023 procedures; however, CMS coverage for low-risk cohorts is expanding at a 19 % CAGR, set to surpass the high-risk curve by 2027. Degenerative bioprosthesis failure within TAVR-in-TAVR, though <5 % today, scales with the surgical valve population implanted two decades ago, implying a 30 % plus annual volume inflection post-2025. Registries show hospitals orienting physician teams around application tiers: high-risk volumes anchor site credentials, while intermediate-risk cases improve EPU utilization above 70 %, the threshold where per-procedure profit equals surgical AVR. Consequently, shifts in application mix exert 3โ4ร leverage on unit forecasts relative to pure population aging, a sensitivity embedded in forward-looking market taxonomy models.