The Single Organ-on-a-Chip Models market refers to the development and application of microfluidic devices that mimic the structure and function of individual organs, such as the liver, kidney, and lung. As a crucial component of the broader Organ-on-a-Chip (OoC) market, Single Organ-on-a-Chip Models have garnered significant attention in recent years due to their potential to revolutionize the field of biomedical research and drug development. The Single Organ-on-a-Chip Models market size was valued at approximately $12.4 million in 2025 and is expected to grow at a compound annual growth rate (CAGR) of 23.1% during the forecast period, driven by increasing demand for personalized medicine, rising investments in biomedical research, and advancements in microfluidics and 3D cell culture technologies. The market forecast suggests a growth outlook of significant expansion, with the global Single Organ-on-a-Chip Models market expected to reach $64.8 million by 2033, driven by industry expansion and the increasing adoption of OoC technology in various applications, including toxicity testing, drug discovery, and regenerative medicine.