Application-level market taxonomy segments demand into hepatocellular carcinoma (HCC), colorectal cancer liver metastases (CRLM), neuroendocrine tumor liver metastases (NETLM), and an other metastatic liver disease residual bucket. HCC represents the dominant clinical indication, propelled by global cirrhosis prevalence and curative bridge-to-transplant protocols, translating into the largest share of radioembolization procedures. CRLM follows as the second largest segment, supported by salvage therapy guidelines post-chemotherapy failure in oxaliplatin-refractory patients. NETLM, though lower in absolute volume, commands premium pricing due to prolonged progression-free survival evidence and multidisciplinary neuroendocrine tumor board adoption. The residual "other" category aggregates breast, ocular melanoma, and cholangiocarcinoma cases, collectively minor but growing amid expanding real-world evidence publications; combined, these four application segments exhaust the addressable market for radioembolization across major healthcare systems.