The Preclinical brain imaging market size surpassed USD 1.65 B in 2025 and, under the 2026-2033 market forecast, is on pace for a 9.4% CAGR to reach USD 3.1 B by 2033, propelled by a surge in genetically engineered rodent models, AI-enabled image analytics, and NIH & Horizon Europe neurodegeneration funding. North America commands >42% share thanks to integrated contract research organizations (CROs) and NIH brain initiative grants, while APAC—led by China, Japan, and South Korea—is the fastest-growing region (11% CAGR) as local biotechs upgrade from ex-vivo histology to in-vivo 7 T systems. Competitive intensity is rising: Thermo Fisher, Bruker, and Siemens Healthineers are bundling cloud-based AI reconstruction, whereas emerging players supply compact PET-MRI inserts, tightening price premiums. Supply-chain resilience is shifting from scarce helium-cooled magnets to cryogen-free magnet blocks, and regulators (FDA, EMA) are harmonizing Good Imaging Practice (GIP) guidelines, accelerating crossover between academic core facilities and pharma outsourcing.