Macro drivers propelling industry expansion include the shift to rapid PCR screening that flags MRSA within 30 minutes, prompting immediate decolonization, and FDA clearances for single-use, unit-dose applicators that reduce cross-contamination risk. Competitive intensity is rising as 3M, GSK, and Clorox Healthcare diversify from traditional mupirocin toward iodine-polymer complexes with lower resistance profiles, while contract manufacturers secure long-term API supply agreements to hedge against iodine price volatility. North America captured ~42 % share in 2025, driven by CMS non-payment policies for SSIs; however, APAC is the fastest-growing region (>11 % CAGR) as India and China adopt mandatory pre-surgical decolonization protocols in tier-1 hospitals. Looking ahead, stakeholders should monitor consumer backlash against antibiotic resistance—fueling OTC povidone-iodine uptake—and supply-chain decoupling that could shift API production from China to U.S.-based continuous-flow plants, reshaping cost structures and regional competitiveness through 2033.