The extracorporeal CO₂ removal ecosystem spans upstream raw material and component suppliers, midstream technology developers and OEMs, and downstream integrators, distributors, and clinical users. Upstream actors deliver specialty membranes, sorbents, and sensors that enable selective CO₂ capture. Midstream participants convert these inputs into certified therapy platforms, embedding control algorithms and safety systems. Downstream, system integrators configure turnkey installations, distributors handle logistics, and service firms provide maintenance and training. End users—intensive‑care units, transplant centers, and pulmonary clinics—operate the final systems under regulatory oversight. Value is created by transforming high‑purity components into clinically validated devices and captured through equipment sales, service contracts, and consumable replenishment. Adoption is shaped by approval pathways, reimbursement structures, and hospital procurement cycles.