Types of Cluster Headache Syndrome Drugs are categorized into triptans, CGRP inhibitors, corticosteroids, and gepants. Triptans remain the first-line acute therapy due to their serotonin receptor agonist mechanism, though side effects limit long-term use. CGRP inhibitors, a newer class, are increasingly prescribed for both acute and preventive roles due to their targeted action on calcitonin gene-related peptide pathways. Corticosteroids, while effective for short-term preventive use, face adoption challenges due to systemic side effects. Gepants, oral CGRP antagonists, represent a fast-growing segment, addressing gaps in non-invasive, long-term treatment options. This market taxonomy highlights therapeutic innovation, with CGRP inhibitors and gepants projected to capture 40% of the market by 2030, driven by their safety profiles and regulatory approvals.