Application segmentation reveals that open-angle glaucoma (OAG) and ocular hypertension (OHT) together absorb 73 % of 2023 sales, but with diverging margin profiles. OAG, the larger segment, is increasingly managed by fixed-combination prostaglandin therapy, relegating brimonidine monotherapy to second- or third-line use; consequently, its growth is volume-driven (CAGR 4.2 %) with aggressive tender pricing. OHT, treated primarily to prevent conversion to glaucoma, exhibits higher price elasticity because therapy duration is shorter and patients pay out-of-pocket in many emerging markets; here, 0.2 % brimonidine formulations retain 38 % share versus generics. Postsurgical ocular hypertension—mainly after cataract or trabeculectomy—represents 11 % of value but 6 % of units, as surgeons favor single-dose vials for sterility, lifting ASP by 2.4×. Finally, off-label neuropathic pain and rosacea-associated erythema constitute <2 % of revenue, yet serve as clinical proof-of-concept platforms for life-cycle management, completing the Brimonidine Tartrate Eye Drops segmentation matrix.