Application-based market taxonomy splits demand across oncology indications whose clinical utility, treatment duration and competitive intensity shape generic penetration curves. Metastatic colorectal cancer (mCRC) remains the largest outlet, representing 41 % of 2023 bevacizumab generics volume; first-line use is protocolized in most guidelines, producing predictable eight-cycle treatment footprints that incentivize tendering authorities to switch to low-cost generics once immunogenicity safety databases exceed 1,000 patient-years. Non-small-cell lung cancer (NSCLC) follows with 29 %; here, generics uptake is constrained by combination with novel TKIs in ongoing trials, so price discounts rarely exceed 40 % without jeopardizing site reimbursement. Ovarian cancer contributes 17 %, characterized by maintenance dosing that doubles exposure duration, making cost per treated patient a key formulary lever. Glioblastoma, renal cell carcinoma and off-label intra-ocular use collectively make up the remaining 13 %; these niches show the steepest year-on-year volatility because small prescriber bases pivot quickly when real-world evidence on safety or visual-acuity outcomes emerges.