Application is a critical axis of Anti–vascular Endothelial Growth Factor Therapy segmentation, with distinct therapeutic domains driving market dynamics. Ophthalmology leads the segment, targeting conditions like age-related macular degeneration (AMD) and diabetic macular edema (DME), where anti-VEGF therapies remain the gold standard for neovascular disease management. Oncology follows, focusing on inhibiting tumor angiogenesis in cancers such as renal cell carcinoma and bladder cancer, with therapies like bevacizumab and ranibizumab dominating clinical practice. The Others category encompasses non-cancerous indications, including proliferative diabetic retinopathy and certain vascular anomalies, reflecting expanding applications. Collectively, these applications shape the market size, with ophthalmology’s high prevalence and oncology’s unmet needs driving growth.