The Animal Plethysmography ecosystem comprises a defined set of upstream, midstream, and downstream actors that collectively transform raw sensor components into actionable physiological data for pre‑clinical research. Upstream, raw material and component suppliers deliver precision pressure transducers, flow channels, and biocompatible housings required for accurate volume measurements. Midstream actors—including OEM manufacturers, technology providers, and system integrators—combine these parts, embed data‑acquisition software, and adapt the solution to laboratory standards, thereby creating the functional plethysmography platform. Downstream, distributors and after‑sales service firms move calibrated systems to research institutions, where end users generate, analyze, and interpret respiratory and metabolic parameters. Value is captured at each stage through product differentiation, software licensing, service contracts, and the generation of high‑resolution data that underpins drug‑development decisions.